Director, Clinical Science at BioAge Labs
United States
$230k - $250k
<meta><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.2;letter-spacing:0.25px;margin:6pt 0px;padding:0px;"><span style="color:rgb(50,62,72);background-color:rgb(255,255,255);font-size:12pt;white-space:pre-wrap;">BioAge Labs (BIOA) is finding new ways to treat disease by targeting the mechanisms of aging, with the ultimate goal of increasing healthy human lifespan. </span><a href="https://bioagelabs.com/" target="_blank" class="css-173makr-linkStyle" style="color:rgb(30,74,169);cursor:pointer;"><u><span style="color:rgb(19,125,161);background-color:rgb(255,255,255);font-size:12pt;text-decoration:underline;white-space:pre-wrap;">https://bioagelabs.com</span></u></a></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.2;letter-spacing:0.25px;margin:6pt 0px;padding:0px;text-align:justify;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">We are seeking an experienced </span><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Director, Clinical Science.</strong></b><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;"> This is a fully remote position, and the successful candidate can live in any of the continental US states.</span></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.2;letter-spacing:0.25px;margin:6pt 0px;padding:0px;text-align:justify;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Position Summary:</strong></b></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.2;letter-spacing:0.25px;margin:0pt 0px;padding:0px;text-align:justify;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Reporting to the Senior Director, Clinical Science, the Director of Clinical Science provides scientific and clinical leadership for Phase 1–3 clinical trials, including first-in-human studies, overseeing protocol development, medical monitoring activities, patient safety review, and day-to-day clinical study execution to advance BioAge's clinical development programs.</span></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.38;letter-spacing:0.25px;margin:14pt 0px 0pt;padding:0px;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Job Duties:</strong></b></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.38;letter-spacing:0.25px;margin:12pt 0px;padding:0px;"><u><span style="color:rgb(0,0,0);font-size:12pt;text-decoration:underline;white-space:pre-wrap;">Clinical trial planning and conduct</span></u></p><ul data-pattern="discCircleSquare" data-depth="1" style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;margin:8px 0px;line-height:1.6;padding:0px 0px 0px 32px;list-style-type:disc;"><li style="color:rgb(0,0,0);margin:12pt 0px 0pt;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Support the physician lead in ongoing medical monitoring activities, including review of subject eligibility, protocol deviations, adverse events, concomitant medications, laboratory results, ECGs, and other clinical data to ensure participant safety and data integrity.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Review prospective patient eligibility and provide clinical guidance to investigators regarding enrollment decisions and protocol interpretation.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Contribute to protocol design, statistical analysis plans, clinical study reports, and investigator brochures; design PK sampling schedules.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Author/review clinical sections of INDs/CTAs, briefing books, meeting requests, and marketing applications; participate in FDA/EMA interactions.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Integrate nonclinical, translational, biomarker, and clinical data to inform decisions.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Provide clinical pharmacology oversight of ongoing clinical trials, ensuring subject safety, protocol compliance, and high-quality study conduct.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Collaborate with investigators and study sites to address protocol-related questions and provide timely scientific and clinical guidance throughout study conduct.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Lead the development, review, and amendment of clinical study protocols, investigator brochures, informed consent forms, medical monitoring plans, and other clinical documents.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Partner with Pharmacovigilance to review safety events, assess safety signals, and contribute to safety monitoring committees and data review meetings.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Work cross-functionally with Clinical Operations, Biostatistics, Data Management, Regulatory Affairs, and Program Management to support clinical development, trial start-up, day-to-day management of ongoing trials, and trial closeout.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px 12pt;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Contribute to the preparation of clinical study reports, regulatory submissions, investigator meeting materials, abstracts, manuscripts, and presentations.</span></li></ul><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.38;letter-spacing:0.25px;margin:12pt 0px;padding:0px;"><u><span style="color:rgb(0,0,0);font-size:12pt;text-decoration:underline;white-space:pre-wrap;">Clinical pharmacology</span></u></p><ul data-pattern="discCircleSquare" data-depth="1" style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;margin:8px 0px;line-height:1.6;padding:0px 0px 0px 32px;list-style-type:disc;"><li style="color:rgb(0,0,0);margin:12pt 0px 0pt;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Develop and execute the clinical pharmacology strategy across programs; own dose selection, optimization and justification (FIH starting dose through registrational dose).</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Provide input on DDI, food effect, hepatic/renal impairment, QT/QTc, and special-population dosing.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Conduct or oversee NCA, population PK, exposure–response, PBPK, and mechanistic PK/PD analyses to support development decisions and regulatory interactions — either hands-on or in collaboration with quantitative scientists/vendors.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px 12pt;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Oversee PK sample strategy, bioanalytical assay development/validation and sample testing at external labs; manage CRO/pharmacometrics vendor deliverables and quality.</span></li></ul><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.38;letter-spacing:0.25px;margin:14pt 0px 0pt;padding:0px;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Required Education & Experience</strong></b></p><ul data-pattern="discCircleSquare" data-depth="1" style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;margin:8px 0px;line-height:1.6;padding:0px 0px 0px 32px;list-style-type:disc;"><li style="color:rgb(0,0,0);margin:12pt 0px 0pt;font-size:11pt;line-height:1.38;letter-spacing:0.25px;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Doctor of Pharmacy (PharmD) or equivalent advanced degree in Clinical Pharmacology, Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, or a related discipline required. </strong></b></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:11pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Active pharmacist or medical licensure is preferred but not required.</span></li></ul><ul data-pattern="discCircleSquare" data-depth="1" style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;margin:8px 0px;line-height:1.6;padding:0px 0px 0px 32px;list-style-type:disc;"><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">5+ years</strong></b><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;"> of progressive experience in clinical drug development within the pharmaceutical or biotechnology industry.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Experience serving as a Clinical Scientist, Clinical Development Scientist, or equivalent role supporting Phase 1–3 clinical trials including supporting medical monitoring.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Experience authoring bioanalytic reports, clinical protocols, protocol amendments, clinical study reports, and regulatory submission documents.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Experience interacting with investigators, CROs, and cross-functional clinical development teams.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px 12pt;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Experience supporting regulatory interactions and health authority submissions.</span></li></ul><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.38;letter-spacing:0.25px;margin:14pt 0px 0pt;padding:0px;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Required Qualifications</strong></b></p><ul data-pattern="discCircleSquare" data-depth="1" style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;margin:8px 0px;line-height:1.6;padding:0px 0px 0px 32px;list-style-type:disc;"><li style="color:rgb(0,0,0);margin:12pt 0px 0pt;font-size:11pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Demonstrated expertise in clinical drug development, including protocol design, medical monitoring, safety data review, and clinical trial execution across Phase 1–3 studies.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:11pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Experience interpreting clinical, laboratory, pharmacokinetic, pharmacodynamic, and safety data to support ongoing clinical development.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:11pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Proven ability to provide day-to-day clinical support to investigators and study te</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:11pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Excellent scientific writing skills with experience authoring and reviewing clinical protocols, investigator brochures, clinical study reports, and regulatory documents.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:11pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Demonstrated ability to collaborate effectively across Clinical Operations, Pharmacovigilance, Biostatistics, Data Management, Regulatory Affairs, Translational Sciences, and Program Management.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:11pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Excellent communication and presentation skills with the ability to communicate complex clinical information to internal and external stakeholders.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px 12pt;font-size:11pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Ability to manage multiple clinical programs in a fast-paced biotechnology environment.</span></li></ul><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.38;letter-spacing:0.25px;margin:12pt 0px;padding:0px;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Other Qualifications:</strong></b></p><ul data-pattern="discCircleSquare" data-depth="1" style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;margin:8px 0px;line-height:1.6;padding:0px 0px 0px 32px;list-style-type:disc;"><li style="color:rgb(0,0,0);margin:12pt 0px 0pt;font-size:11pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Modeling software proficiency is a plus: NONMEM, Phoenix WinNonlin, Monolix, R (± Simcyp/GastroPlus/Python), or other PBPK platformsams, including protocol interpretation, subject eligibility review, and management of clinical trial questions.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px 12pt;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Prior experience in a clinical-stage biotechnology company is highly desirable.</span></li></ul><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.2;letter-spacing:0.25px;margin:0pt 0px;padding:0px;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Our company</strong></b></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.2;letter-spacing:0.25px;margin:0pt 0px;padding:0px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">BioAge is a clinical-stage biopharmaceutical company harnessing the biology of human aging to develop new therapies for metabolic diseases. The Company’s human-first discovery platform analyzes proprietary multi-omics data captured over decades to identify molecular pathways that drive metabolic aging and disease. BioAge’s lead program, BGE-102, is a potent, orally available, brain-penetrant NLRP3 inhibitor being developed for diseases driven by inflammation. The Company is also advancing oral and injectable APJ agonists—exercise mimetics with the potential to enhance incretin-driven weight loss and restore healthy body composition in obesity. BioAge’s discovery platform is validated by ongoing research collaborations with Novartis and Lilly. BioAge has been listed on Nasdaq (BIOA) since 2024. For additional information about BioAge, visit the company’s website at https://bioagelabs.com.</span></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;"><br></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.2;letter-spacing:0.25px;margin:0pt 0px;padding:0px;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Our workplace</strong></b></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.2;letter-spacing:0.25px;margin:0pt 0px;padding:0px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">BioAge offers competitive salary, a comprehensive compensation package, and generous paid time off in addition to company-observed holidays. We provide comprehensive health and wellness benefits (medical, dental, and vision insurance) and a 401(k) retirement savings plan with matching employer contributions, and we support families through childcare and fertility benefits. We also pride ourselves in giving employees many opportunities for career development, including a generous annual budget for continued learning and a dedication to training and skill development. Many positions (including this one) are remote, allowing our team members to work from anywhere. The salary for this role is expected to be approximately $230,000 - $250,000, depending on experience. We are open to the concept that different experience levels add value to the team in different ways, and therefore will consider a variety of experience and offer commensurate pay.</span></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;"><br></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.2;letter-spacing:0.25px;margin:0pt 0px;padding:0px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">At BioAge, we embrace diversity and differences while we learn from each other, and we believe that every team member has an important role to play. We are an equal opportunity employer. BioAge prohibits discrimination and harassment of any type and affords equal employment opportunities to employees and applicants without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law. BioAge conforms to the spirit as well as to the letter of all applicable laws and regulations.</span></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;"><br><br><br><br><br></p>
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