Senior Manager, Sales &amp; Operations Planning (S&amp;OP) at Cabaletta Bio Inc.

Senior

Sales & Operations Planning

Supply Chain Management

Demand Planning

+5 more

Job Description

Position Title: Senior Manager, Sales & Operations Planning (S&OP)

Location: (Remote)

Reports to: Director, Network Planning

Cabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developing and launching curative targeted cell therapies designed specifically for patients with autoimmune diseases. The CABA™ platform encompasses two complementary strategies which aim to advance the discovery and development of engineered T cell therapies with the potential to become deep and durable, perhaps curative, treatments for a broad range of autoimmune diseases. The lead CARTA (Chimeric Antigen Receptor T cells for Autoimmunity) strategy is prioritizing the development of rese-cel, a 4-1BB-containing fully human CD19-CAR T cell investigational therapy. Rese-cel is currently being evaluated in the RESET™ (REstoring SElf-Tolerance) clinical development program spanning multiple therapeutic areas, including rheumatology, neurology and dermatology. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, please visit www.cabalettabio.com and connect with us on LinkedIn.

Uniquely Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing cures, where a patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew.

We’re proud to be a Great Place to Work-Certified™ company! #GPTWcertified Check out what our employees say makes working here so great: Working at Cabaletta Bio Inc | Great Place to Work®

About the Position:

Reporting to the Director, Network Planning, the Senior Manager, Sales & Operations Planning (S&OP) is responsible for leading the end-to-end S&OP process across Cabaletta Bio's cell therapy supply chain. This role ensures alignment between patient demand, manufacturing capacity, inventory strategies, and financial objectives through a structured planning process and effective cross-functional decision-making.

This role leads the monthly S&OP/IBP cycle, providing visibility into patient demand signals, supply constraints (including CDMO capacity, lead times, and regulatory factors), and associated risks. The Sr. Manager drives scenario planning, aligns operational plans and leads a team responsible for global supply planning and inventory management.

Responsibilities:

Lead the global monthly S&OP cycle, including Demand Review and Supply Review, and support the Executive S&OP. Partner with Clinical, Commercial, Finance, Quality, Regulatory, and Manufacturing to produce a single, aligned operating plan.
Build and maintain a consensus demand plan for clinical and commercial products, informed by patient enrollment, apheresis scheduling, and treatment forecasts, and clearly communicate gaps, risks, and opportunities.
Prepare executive S&OP materials that frame key decisions, trade-offs, and recommendations, and track decisions and action items through to closure.
Oversee the development and maintenance of end-to-end supply models across the cell therapy value chain, including master cell banks (MCB), plasmids, lentiviral vector (LVV), apheresis, drug product (DP), and product control and reference standards.
Guide the team in modeling long-range requirements for MCB, plasmid, and LVV, accounting for campaign timing, lot yields, release testing lead times, and stability, so that critical starting materials are available ahead of patient demand.
Ensure patient demand is accurately translated into apheresis collection and DP manufacturing slot requirements, incorporating vein-to-vein timelines, manufacturing success rates, and capacity constraints.
Ensure supply plans for product control and reference standards support release testing, stability programs, and comparability studies, including timely replenishment and requalification.
Identify, quantify, and escalate supply constraints, including CDMO manufacturing slot capacity, material and manufacturing lead times, and regulatory dependencies such as approvals, site registrations, and post-approval changes.
Partner with Supplier Management and CDMOs on forecast alignment, slot offer communication, and long-range capacity planning.
Lead scenario planning on supply, inventory, and capacity risks, translate the results into clear options for executive decisions, and recommend network design changes where structural issues arise.
Oversee inventory strategy execution for critical materials, including reconciliation, shelf-life and expiry management, and minimizing excess and obsolete (E&O) write-offs.
Lead, coach, and develop a team of supply planning and inventory professionals, building modeling capability and succession depth.
Other duties as assigned.

Qualifications:

Bachelor’s degree or equivalent (preferred concentration in Engineering, Supply Chain, or Business Management/Sciences); advanced degree (MBA or MS) a plus.
7-10 years of progressive supply chain experience spanning demand planning, supply planning, and/or S&OP. Relevant experience in autologous cell & gene therapy is ideal.
People leadership experience
Demonstrated ability to facilitate executive-level discussions, synthesize complex data into clear recommendations, and influence cross-functional stakeholders.
Experience with ERP (NetSuite preferred) and planning systems and advanced Excel skills; experience with BI/visualization tools (e.g., Power BI, Tableau) a plus.
APICS (CPIM/CSCP) or similar certification preferred.
Working knowledge of regulatory frameworks (FDA, EMA, etc.), GMP manufacturing, and GMP storage requirements.

Our name – Cabaletta – is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression.

For more information, please visit https://www.cabalettabio.com/join-our-crew

Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans.

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.

Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation.

And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.

#LI-REMOTE

Requirements

ensure supply plans for product control and reference standards support release testing, stability programs, and comparability studies, including timely replenishment and requalification.
identify, quantify, and escalate supply constraints, including cdmo manufacturing slot capacity, material and manufacturing lead times, and regulatory dependencies such as approvals, site registrations, and post-approval changes.
partner with supplier management and cdmos on forecast alignment, slot offer communication, and long-range capacity planning.
lead scenario planning on supply, inventory, and capacity risks, translate the results into clear options for executive decisions, and recommend network design changes where structural issues arise.
oversee inventory strategy execution for critical materials, including reconciliation, shelf-life and expiry management, and minimizing excess and obsolete (e&o) write-offs.
lead, coach, and develop a team of supply planning and inventory professionals, building modeling capability and succession depth.
other duties as assigned.
bachelor’s degree or equivalent (preferred concentration in engineering, supply chain, or business management/sciences); advanced degree (mba or ms) a plus.

Benefits

Pay in Crypto

Skills

Sales & Operations Planning

Supply Chain Management

Demand Planning

Supply Planning

Inventory Management

Cell therapy

Scenario Planning

Capacity Planning

Ready to Apply?

Join Cabaletta Bio Inc. today

Posted 5 days ago

More Sales roles you might like

Discover similar opportunities from companies that are also hiring remotely.

Account Executive

MarketFully

Full Time

8 hours ago

🌎 Where: 100% Remote, United States 🤝 Type: Full-time, salaried Multilingual Content Marketing, Social & Technology Solutions MarketFully helps ambitious brands grow in every market they operate in.

United States

Account Executive

Senior

Sales

Account Management

Consultative Selling

+5 more

Salesforce Administrator

MarketFully

Full Time

9 hours ago

🌎 Where: Argentina or Colombia - 100% Remote 🤝 Type: Full-time, via our employer of record About MarketFully Group We've combined four established companies - MotionPoint, Key Content, GetGloby, and Social Element - into one company: MarketFully.

Worldwide

Account Executive

Senior

Salesforce Administration

Apex

Lightning Web Components

+5 more

Strategic Sales Rep (Westcoast/PST)

RR Donnelley

Full Time

$50k - $150k

12 hours ago

Company Description RRD is a leading global provider of marketing, packaging, print, and supply chain solutions that elevate engagement across the complete customer journey.

United States

Account Executive

Mid

B2B Sales

Cold Calling

Business Development

+5 more

Explore more remote openings

Browse fresh listings from our global community of remote-friendly teams.

Sr Specialist Analyst (Technology Research, Quantitative research)

Gartner

Full Time

4 hours ago

Senior Specialist Analyst — Forecast and Market Share (F&MS) What makes Gartner Business and Technology Insights a great fit for you? When you join Gartner Business and Technology Insights, you’ll be part of a leading-edge team that values expert insights, bold ideas, and intellectual courage.

India

Data

Data Science

Mid

Quantitative Research

Market Analysis

Data Modeling

+5 more

Senior DevOps Engineer (India)

Karat

Full Time

6 hours ago

We're Karat , the world's largest interviewing company. Karat is transforming organizations around the world. We provide a powerful system for technical leaders at companies like PayPal, Atlassian, and Citi who want to take control of how they hire top engineers, elevate their teams and…

India

DevOps / SRE

Senior

DevOps

Site reliability engineering

AWS

+5 more

Senior Data Engineer (India)

Karat

Full Time

6 hours ago

India

Haag, a Salas O'Brien Company

Senior

Data engineering

SQL

Python

+5 more

Career Framework Manager

Full Time

$95k - $120k

6 hours ago

Manager, Career Framework At Salas O’Brien we tell our clients that we’re engineered for impact. This passion for making a difference applies just as much to our team as it does to our projects.

United States

Senior

Talent Management

Workforce Planning

Organizational Development

+5 more

Director of Software Engineering (India)

Karat

Full Time

6 hours ago

India

Staff

Software Engineering

Engineering Management

SaaS

+5 more

Technical Account Manager

Samsara

Full Time

6 hours ago

Who we are Samsara (NYSE: IOT) is the pioneer of the Connected Operations™ Cloud, which is a platform that enables organizations that depend on physical operations to harness Internet of Things (IoT) data to develop actionable insights and improve their operations.

Mexico

Check Point Software Technologies

Senior

Technical Account Management

Customer Success

Consultative Problem Solving

+5 more

Team Leader, ERM Customer Success Americas

Full Time

7 hours ago

Company Description Cyberint , a market leader in External Risk Management, helping organizations to accelerate the detection, response and remediation of their external threats, was recently acquired by Check Point and is looking for a  Customer Success Team Leader to bolster our Customer…

United States

Customer Success

Customer Success Management

Senior

Customer Success

Team Leadership

Cybersecurity

+5 more

Head of Product

Sharp Performance

Full Time

9 hours ago

The Opportunity Sharp Performance is hiring a Head of Product to own our product vision, strategy, and roadmap, and to build a product that first responders want to open every day.

United States

Senior

Product Strategy

Product Roadmap

Technical Fluency

+5 more

Senior Data & AI Engineer

CareDx, Inc.

Full Time

$126k - $187k

9 hours ago

CareDx is a leading precision medicine diagnostics company advancing care in transplant, specialty oncology, and cell therapy. Through our innovative portfolio of molecular diagnostics, digital health solutions, AI-powered data and analytics, and patient support services, we partner with healthcare…

United States

Machine Learning

Senior

Python

SQL

Clinical NLP

+5 more

Customer Success Manager

Pindrop

Full Time

$88k - $106k

9 hours ago

Who We Are Pindrop is a cybersecurity company delivering continuous identity verification across voice, video, and digital interactions. Powered by the Pindrop Intelligence Network, our unified trust platform helps enterprises answer three critical questions: Is this identity synthetic?

United States

Customer Success

Customer Success Management

Mid

Customer Success

Account Management

SaaS

+5 more

Senior Failure Analysis Engineer, Medium Voltage Transformers and Switchgear

SMA America

Full Time

$106k - $150k

10 hours ago

Why Work at SMA America Power the future. Build your career at SMA America. As the U.S. subsidiary of SMA Solar Technology AG, we have been at the forefront of solar inverter technology since 1981, developing solutions that make photovoltaic power plants simpler, more reliable, safer, and more cost…

United States

Senior

Failure Analysis

Transformers

Switchgear

+5 more

Tester de Automação - Remoto

Movilges

Full Time

10 hours ago

Estamos a recrutar Tester de Automação - Remoto (m/f) para reforçar a nossa equipa com possibilidade de trabalhar em regime remoto. O que procuramos: • Licenciatura em Engenharia Informática ou áreas similares (preferencial); • 3 anos de experiência (mínimo) com…

Portugal