Associate Director, Real-World Evidence & Epidemiology at Natera

United States

$176k - $220k

<p><strong>POSITION SUMMARY: </strong></p> <p>We are seeking a <strong>Principal Clinical Scientist / Associate Director of Real-World Evidence &amp; Epidemiology</strong> to drive observational evidence strategy for our Early Cancer Detection (ECD) portfolio. Population-scale liquid biopsy screening requires robust real-world evidence demonstrating clinical utility, clinical decision-making impact, and downstream patient outcomes. This ownership role uses real-world datasets to accelerate standard-of-care implementation across oncology diagnostics. Working with a builder mindset, you will partner across Clinical Science, Medical Affairs, Market Access, and Data Science to convert population-scale observational data into actionable clinical implementation strategies.</p> <p><strong>PRIMARY RESPONSIBILITIES: </strong></p> <p><strong>Epidemiology and Observational Research Strategy</strong></p> <ul> <li>Lead the design, protocol development, and execution of prospective observational studies, registries, and retrospective database assessments across early cancer detection programs</li> <li>Shape post-market evidence generation strategies by isolating critical clinical utility and implementation hurdles that can be resolved via real-world data assets</li> <li>Translate clinical and market requirements into rigorous, practical study designs, specifying target populations, clinical endpoints, and analytic frameworks</li> <li>Systematically identify and mitigate sources of bias, confounding factors, and missing data variance inherent in real-world healthcare datasets</li> <li>Design protocols evaluating clinical utility across diverse populations, ensuring the data generated directly supports precision interventions for individual patients and families</li> </ul> <p><strong>Cross-Functional Scientific Leadership</strong></p> <ul> <li>Partner across Clinical Science, Medical Affairs, Product Management, and Market Access to prioritize evidence generation initiatives based on regulatory and clinical urgency</li> <li>Collaborate with Biostatistics and Data Science to engineer statistical analysis plans, interpret data findings, and deliver clinical contextualization</li> <li>Extract empirical evidence from early commercial and Laboratory Developed Test (LDT) cohorts to isolate adoption variables, diagnostic compliance, and real-world clinical workflows</li> <li>Deliver real-world data assets that dismantle payer coverage barriers and ground product positioning strictly in clinical utility metrics</li> </ul> <p><strong>Evidence Dissemination and External Engagement</strong></p> <ul> <li>Convert complex epidemiological findings into clear, high-integrity scientific narratives for internal product governance and external healthcare stakeholders</li> <li>Spearhead the development of peer-reviewed abstracts, posters, presentations, and core manuscripts for major oncology and diagnostic conferences</li> <li>Engage with external clinical collaborators, investigators, and key opinion leaders (KOLs) to advance the platform base for early cancer detection</li> </ul> <p><strong>QUALIFICATIONS: </strong></p> <ul> <li>Advanced degree (PhD, MPH, MS, PharmD, or equivalent scientific credential) in epidemiology, health outcomes research, biostatistics, or a highly quantitative field</li> <li>7+ years of experience leading real-world evidence generation, observational clinical research, or HEOR portfolios within the life sciences industry</li> <li>Documented experience executing observational studies across the entire asset lifecycle, from initial protocol drafting through statistical analysis and publication</li> <li>Deep data competency across real-world data sources, including longitudinal medical claims, electronic health records (EHR), and clinical registries</li> <li>Direct experience in oncology clinical trials, molecular diagnostics, or early cancer detection programs is preferred</li> </ul> <p><strong>KNOWLEDGE, SKILLS, AND ABILITIES: </strong></p> <ul> <li>Take full ownership of complex clinical portfolios as an autonomous strategist</li> <li>Rigorous analytical skills with the ability to pressure-test study assumptions and ground major milestones entirely in data</li> <li>Communicate with technical precision across matrixed lines to align R&amp;D, commercial, medical, and lab operations functions</li> <li>Strong ownership mindset with the capability to balance scientific rigor, speed, and trial resource constraints under tight timelines</li> <li>Comfort with ambiguity and an evolving product surface as underlying genomic science advances</li> </ul> <p>&nbsp;</p><div class="content-pay-transparency"><div class="pay-input"><div class="description">The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years &amp; depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.</div><div class="title">Remote USA</div><div class="pay-range"><span>$176,000</span><span class="divider">&mdash;</span><span>$220,000 USD</span></div></div></div><div class="content-conclusion"><p><strong>OUR OPPORTUNITY</strong></p> <p>Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.</p> <p>The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.</p> <p><strong>WHAT WE OFFER</strong></p> <p>Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!</p> <p>For more information, visit <a href="http://www.natera.com/" data-cke-saved-href="http://www.natera.com/">www.natera.com</a>.</p> <p>Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.</p> <p>All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.</p> <p><em>If you are based in California, we encourage you to read this important information for California residents.&nbsp;</em></p> <p>Link: <a href="https://www.natera.com/notice-of-data-collection-california-residents" target="_blank">https://www.natera.com/notice-of-data-collection-california-residents/</a></p> <p>Please be advised that Natera will reach out to candidates with a @<a href="http://natera.com/" target="_blank" data-saferedirecturl="https://www.google.com/url?q=http://natera.com&amp;source=gmail&amp;ust=1657718972773000&amp;usg=AOvVaw3zRwaIiu7070kJKNG4hjRm">natera.com</a>&nbsp;email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.</p> <p>For more information:<br>- <a href="https://www.bbb.org/article/tips/12261-bbb-tip-employment-scams" target="_blank">BBB announcement on job scams</a>&nbsp;<br>- <a href="https://www.fbi.gov/investigate/cyber" target="_blank">FBI Cyber Crime resource page</a>&nbsp;</p></div>