Director, DMPK (or Senior Director) at BioAge Labs
United States
$230k - $290k
<meta><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.2;letter-spacing:0.25px;margin:6pt 0px;padding:0px;text-align:justify;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">We are seeking an experienced </span><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Director, DMPK (or Senior Director)</strong></b><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">. This is a fully remote position, and the successful candidate can live in any of the continental US states.</span></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.2;letter-spacing:0.25px;margin:6pt 0px;padding:0px;text-align:justify;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Position Summary:</strong></b></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.2;letter-spacing:0.25px;margin:0pt 0px;padding:0px;text-align:justify;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Reporting to the VP, Non Clinical Development, the Director, DMPK will lead the company's DMPK and translational pharmacology function, collaborating across disciplines to optimize candidate selection, clinical translation, and regulatory success.</span></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.38;letter-spacing:0.25px;margin:14pt 0px 0pt;padding:0px;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Job Duties:</strong></b></p><ul data-pattern="discCircleSquare" data-depth="1" style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;margin:8px 0px;line-height:1.6;padding:0px 0px 0px 32px;list-style-type:disc;"><li style="color:rgb(0,0,0);margin:12pt 0px 0pt;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Lead the Drug Metabolism and Pharmacokinetics (DMPK) and translational pharmacology strategy across BioAge's pipeline, supporting programs from lead optimization through IND-enabling studies and clinical development.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Develop integrated DMPK and translational pharmacology strategies to optimize absorption, distribution, metabolism, excretion (ADME), exposure, tissue distribution, pharmacokinetic/pharmacodynamic (PK/PD) relationships, and human dose prediction.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Design, oversee, and interpret in vitro and in vivo DMPK, ADME, metabolite identification, and bioanalytical studies to enable informed candidate selection and progression decisions.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Partner closely with Medicinal Chemistry, Discovery Biology, Biomarkers, Toxicology, Clinical Pharmacology, and Clinical Development to integrate DMPK data into overall program strategy and decision-making.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(31,31,31);font-size:12pt;white-space:pre-wrap;">Design, direct, and interpret quantitative PK/PD, exposure-response, and PBPK/population-PK modeling that integrates nonclinical and clinical data, driving mechanism-based dose selection and model-informed drug development</span><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Provide scientific leadership for first-in-human dose projections, clinical pharmacology strategy, and translational plans that bridge preclinical findings to clinical development.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Identify and proactively address DMPK risks and optimization opportunities, including drug-drug interaction potential, metabolite characterization, formulation considerations, and species translation.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Select, manage, and oversee external CROs and strategic partners conducting DMPK, bioanalytical, and translational pharmacology studies, ensuring high scientific quality, timely execution, and regulatory compliance.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Author and review DMPK and clinical pharmacology sections of regulatory submissions, including INDs, CTAs, Investigator's Brochures, and related documentation, and support interactions with global regulatory authorities.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Build and continuously improve DMPK capabilities, scientific standards, and decision-making frameworks, evaluating and adopting emerging approaches in quantitative pharmacology and translational science to strengthen BioAge's platform.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Communicate DMPK strategy, data, and recommendations to cross-functional teams, leadership, and external partners to drive key development and portfolio decisions.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px 12pt;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Mentor and develop internal scientific talent while fostering a collaborative, innovative, and data-driven culture across cross-functional teams.</span></li></ul><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.38;letter-spacing:0.25px;margin:14pt 0px 0pt;padding:0px;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Required Education & Experience</strong></b></p><ul data-pattern="discCircleSquare" data-depth="1" style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;margin:8px 0px;line-height:1.6;padding:0px 0px 0px 32px;list-style-type:disc;"><li style="color:rgb(0,0,0);margin:12pt 0px 0pt;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Drug Metabolism, or a related scientific discipline.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">12+ years of relevant biotechnology and/or pharmaceutical industry experience following completion of a Ph.D., with demonstrated success advancing small molecule therapeutics from discovery through early clinical development.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Proven experience leading DMPK strategy for multiple drug discovery and development programs, including candidate selection, IND-enabling studies, and first-in-human dose projection.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Demonstrated experience supporting regulatory submissions, including authorship or review of DMPK and clinical pharmacology sections of INDs, CTAs, Investigator's Brochures, and related regulatory documents.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Experience serving as the DMPK representative on multidisciplinary program teams and influencing key portfolio and development decisions.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Experience selecting, managing, and overseeing external CROs and scientific collaborators.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px 12pt;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Experience mentoring scientists and providing technical leadership within cross-functional organizations.</span></li></ul><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.38;letter-spacing:0.25px;margin:14pt 0px 0pt;padding:0px;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Required Qualifications</strong></b></p><ul data-pattern="discCircleSquare" data-depth="1" style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;margin:8px 0px;line-height:1.6;padding:0px 0px 0px 32px;list-style-type:disc;"><li style="color:rgb(0,0,0);margin:12pt 0px 0pt;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Deep expertise in drug metabolism and pharmacokinetics (DMPK), ADME, bioanalysis, metabolite identification, and disposition of small molecule therapeutics.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Strong understanding of translational pharmacology, pharmacokinetic/pharmacodynamic (PK/PD) relationships, exposure-response analyses, and quantitative approaches to dose selection.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Demonstrated ability to integrate DMPK, pharmacology, biomarker, and toxicology data to inform candidate optimization and development strategy.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Working knowledge of regulatory expectations for DMPK and clinical pharmacology, including FDA, EMA, and ICH guidance.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Strong scientific judgment with the ability to evaluate complex data, identify development risks, and recommend practical solutions.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Excellent written and verbal communication skills, including experience presenting to executive leadership and authoring high-quality scientific and regulatory documents.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px 12pt;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Proven ability to thrive in a collaborative, fast-paced, remote biotechnology environment while effectively managing multiple priorities.</span></li></ul><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.38;letter-spacing:0.25px;margin:14pt 0px 0pt;padding:0px;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Preferred Qualifications</strong></b></p><ul data-pattern="discCircleSquare" data-depth="1" style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;margin:8px 0px;line-height:1.6;padding:0px 0px 0px 32px;list-style-type:disc;"><li style="color:rgb(0,0,0);margin:12pt 0px 0pt;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Experience with quantitative pharmacology approaches, including physiologically based pharmacokinetic (PBPK) modeling and/or population pharmacokinetic analyses.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Experience in age-related diseases, metabolic disease, obesity, cardiometabolic disease, or other chronic disease therapeutic areas.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Experience building DMPK capabilities and scientific strategy within a growing biotechnology company.</span></li><li style="color:rgb(0,0,0);margin:0pt 0px 12pt;font-size:12pt;line-height:1.38;letter-spacing:0.25px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Prior direct people management experience is a plus</span></li></ul><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.2;letter-spacing:0.25px;margin:0pt 0px;padding:0px;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Our company</strong></b></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.2;letter-spacing:0.25px;margin:0pt 0px;padding:0px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">BioAge is a clinical-stage biopharmaceutical company harnessing the biology of human aging to develop new therapies for metabolic diseases. The Company’s human-first discovery platform analyzes proprietary multi-omics data captured over decades to identify molecular pathways that drive metabolic aging and disease. BioAge’s lead program, BGE-102, is a potent, orally available, brain-penetrant NLRP3 inhibitor being developed for diseases driven by inflammation. The Company is also advancing oral and injectable APJ agonists—exercise mimetics with the potential to enhance incretin-driven weight loss and restore healthy body composition in obesity. BioAge’s discovery platform is validated by ongoing research collaborations with Novartis and Lilly. BioAge has been listed on Nasdaq (BIOA) since 2024. For additional information about BioAge, visit the company’s website at https://bioagelabs.com.</span></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;"><br></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.2;letter-spacing:0.25px;margin:0pt 0px;padding:0px;"><b><strong style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">Our workplace</strong></b></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.2;letter-spacing:0.25px;margin:0pt 0px;padding:0px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">BioAge offers competitive salary, a comprehensive compensation package, and generous paid time off in addition to company-observed holidays. We provide comprehensive health and wellness benefits (medical, dental, and vision insurance) and a 401(k) retirement savings plan with matching employer contributions, and we support families through childcare and fertility benefits. We also pride ourselves in giving employees many opportunities for career development, including a generous annual budget for continued learning and a dedication to training and skill development. Many positions (including this one) are remote, allowing our team members to work from anywhere. The salary for this role is expected to be approximately $230,000 - $290,000, depending on experience. We are open to the concept that different experience levels add value to the team in different ways, and therefore will consider a variety of experience and offer commensurate pay.</span></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;"><br></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.2;letter-spacing:0.25px;margin:0pt 0px;padding:0px;"><span style="color:rgb(0,0,0);font-size:12pt;white-space:pre-wrap;">At BioAge, we embrace diversity and differences while we learn from each other, and we believe that every team member has an important role to play. We are an equal opportunity employer. BioAge prohibits discrimination and harassment of any type and affords equal employment opportunities to employees and applicants without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law. BioAge conforms to the spirit as well as to the letter of all applicable laws and regulations.</span></p><p style="font-family:"Basel Grotesk",Arial,sans-serif;font-size:11pt;font-weight:400;line-height:1.6;letter-spacing:0.25px;margin:4px 0px;padding:0px;"><br><br><br><br><br></p>
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